VITAMIN E EFFECT IN A RAT MODEL OF TOLUENE DIISOCYANATE-INDUCED ASTHMA
نویسندگان
چکیده
منابع مشابه
Vitamin E effect in a rat model of toluene diisocyanate-induced asthma
BACKGROUND AND AIM The aim of the study was to evaluate vitamin E effect upon oxidative stress associated with toluene -2, 4-diisocyanate (TDI)-induced asthma in rats. METHODS The five study groups were: control, vehicle, TDI, vehicle+E, TDI+E. TDI animals were sensitized by nasal administration of TDI 10% (5μl/nostril) between days 1-7 and 15-21. Between days 22-28 groups TDI+E and vehicle+E...
متن کاملPersistence of toluene diisocyanate-induced asthma despite negligible workplace exposures.
Six polyurethane foam workers were shown to have TDI-induced asthma by specific inhalation challenge testing. All remained in the workplace in jobs with minimal TDI exposures. Mean and time-weighted average exposure concentration for the asthmatic group was 0.64 +/- 0.46 ppb, less than 5 percent of the permissible exposure limit and significantly less (p less than 0.01) than the mean TWA exposu...
متن کاملImmunological determinants in a murine model of toluene diisocyanate-induced asthma.
OBJECTIVES Diisocyanates (DIC) are highly reactive, low-molecular-weight chemicals which are the leading cause of occupational asthma (OA). The aim of the study was to analyze certain aspects of the pathogenesis of allergic inflammation in the airways induced by toluene diisocyanate (TDI) in an experimental model in mice. MATERIALS AND METHODS The experiment was carried out on 50 female BALB/...
متن کاملLong-term follow-up of toluene diisocyanate-induced asthma.
Eighty-seven cases of occupational asthma induced by toluene diisocyanate (TDI) were diagnosed by an inhalation challenge with TDI and methacholine. After an average follow-up interval of 11 yrs, all subjects were re-examined. Of the 87 subjects examined, 13 (15%) had remained in the same job, 44 (50.5%) had been removed from exposure for <10 yrs and 30 (34.5%) had been removed for >10 yrs. The...
متن کاملRole of intercellular adhesion molecule-1 in a murine model of toluene diisocyanate-induced asthma.
BACKGROUND Adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1) are thought to contribute to the airway inflammation and airway hyper-responsiveness (AHR) of allergic asthma. Some differences from allergic asthma have been noted, including airway neutrophilia, and the involvement of ICAM-1 in toluene diisocyanate (TDI) asthma is currently unclear. OBJECTIVE We utilized mice l...
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ژورنال
عنوان ژورنال: Medicine and Pharmacy Reports
سال: 2016
ISSN: 2668-0572,2602-0807
DOI: 10.15386/cjmed-611